Aspergillus Niger Tiegh: An Endophyte from Gymnema Sylvestre for its Antihyperglycemic Potential

By : G. M. Vidyasagar, Roopa S.G, MD. Liyakat Ahmed, Shankaravva Babanagare, Sangeeta M.K, Ambika Vasantkumar

Page No: 167-173

Abstract
Traditional medicinal plant Gymnema sylvestre is used to cure many diseases and its availability in nature is very rare. In the present research, as an alternate to the host plant, fungal endophyte from leaves of G. sylvestre was isolated and based on morphological and molecular characterization the isolate was identified as Aspergillus niger Tiegh. The ethyl acetate extract of the fungus was further employed for qualitative and quantitative analysis of secondary metabolite, revealed presence of saponin, tannin, flavonoids, glycosides, phenol and alkaloid. The oral glucose tolerance test in fungal ethyl acetate extract (250mg/kg body weight) treated Albino mice has shown reduced level of blood glucose compared to the negative control group, whereas compared with standard drug no significant reduction recorded.

Authors :
G. M. Vidyasagar, Roopa S.G., MD. Liyakat Ahmed, Shankaravva Babanagare, Sangeeta M.K., and Ambika Vasantkumar
Department of Post Graduate Studies and Research in Botany Gulbarga University, Gulbarga–585 106, Karnataka, India.
 

DOI: https://doi.org/10.32381/JPSR.2021.37.01.20