Antibacterial Activity of Mikania micrantha Kunth, Corchorus capsularis L. and Centella asiatica (L.) Urban Plant against Staphylococcus aureus: An in vitro Analysis

By : Rupjyoti Neog, Namrita Kola

Page No: 235-241

Abstract
Plant derivatives are gaining significant momentum in the field of medical science due to their broadspectrum therapeutic properties owing to drug resistance and harmful side effects associated with synthetic drugs. Staphylococcus aureus, is known for its multidrug-resistance against common antibiotics and is responsible for spreading various pathogenic diseases. The present in vitro investigation aimed to assess the antibacterial potential of methanolic extracts of Mikania micrantha, Corchorus capsularis and Centella asiatica plant against the gram-positive bacteria S. aureus (MTCC 7443) strain. Employing the agar well diffusion method, antibacterial activity at various concentrations of the plant extracts were evaluated. The results demonstrated a significant zone of inhibition (p≤0.05) for all the selected plant extracts. The plant extract from Mikania micrantha exhibited an inhibition zone of 14.7±0.71 mm and 19.33±0.58 mm; Corchorus capsularis showed 9.44±0.69 mm and 12.11±0.38 mm, while Centella asiatica showed 11.33±0.96 mm and 13.22±0.38 mm at 80 mg and 120 mg concentrations, respectively. The positive control demonstrated an inhibition zone of 11.23 mm whereas, the negative control showed no zone of inhibition. These findings suggest that the plant extracts possess a broad-spectrum antibacterial activity against the pathogenic bacterial strain, indicating their potential as a source of natural antibacterial compounds.

Authors:
Rupjyoti Neog and Namrita Kola
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
 

DOI: https://doi.org/10.32381/JPSR.2024.40.02.4