Bio-Efficacy of Flavonoid Phytocompound Isolated From Acmella Calva (Dc.) R.K. Jansen

By : K. Priyadharshni, P. Shanthi

Page No: 235-243

Abstract
The phytocompound 5,7,3’,4’–Flavon-3-ol isolated and characterized through spectral studies was analyzed for its anticariogenic activity through disc diffusion method and In-silico analysis. It was carried against dental caries causing microbes such as Streptococcus mutans at different concentration (20, 40, 60, 80, 100, 120, 140 and 160 μg/ml) of which the maximum zone of inhibition was noticed at 160 μg/ml. In in-silico analysis, the molecular docking of phytocompound was analyzed against 4 proteins of the pathogen which were retrieved from PDB database. The phytocompound 5,7,3’,4’ – Flavon-3-ol showed good response against all proteins. Among these, the highest ligand and protein interaction was noticed in 3AIE protein of Streptococcus mutans. The flavonoid compound was tested for its drug likeness and ADME/T properties. The results revealed that the compound accepted the three rule out of four in Lipinski rule of five. ADME properties and toxicity of the phytocompound showed oral bioavailability which are under permissible limit. From the present investigation, it was proved that the phytocompound 5,7,3’,4’–Flavon-3-ol is harmless and effect potent against dental caries causing microbes.

Authors :
K. Priyadharshni : Reseach scholar, Department of Botany, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India.
P. Shanthi : Dean of Life Science, Assistant Professor, Department of Botany, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India
 

DOI: https://doi.org/10.32381/JPSR.2023.39.02.25