Phytochemical screening of Celastrus peniculatus and Bacopa monnieri for neuroprotective capacity

By : Pallav Kaushik Deshpande, Ragini Gothalwal

Page No: 153-158

Abstract
Medicinal properties of plants are dependent on the presence of certain phytoconstituent. Various plants exhibits neuroprotective and cognitive enhancing effects. Phytoconstituents shows capacity to modulate the cholinergic system and to contrast oxidative stress. Individual alkaloids act as agonists and antagonists to a variety of neurotransmitter systems, for instance, direct binding to neuroreceptors and interference with neurotransmitter metabolism (e.g. cholinesterase inhibition), signal transduction, and ion channel function or by mimicking the structure of endogenous neurochemicals. In this study we had investigated the fundamental scientific bases for the use of medicinal plant by defining qualitative evaluation of crude phytochemical constituents present in Celastrus peniculatus and Bacopa monnieri both the plants are known to local folks and widely used to stimulate the nervous system but, Scientific validation is lacking. Successive extraction method was adopted by using various solvents according to polarity, from lowest to high (hexane, pet ether, ethly ether, acetone, methanol, ethanol, water). Extractive value in % for seeds of Celastrus paniculatus with various extract was 45.59±1.43, 47.47±0.45, 56.09±0.45, 64.46±0.43, 67.45±1.34, 69.34±1, 78.2±1.32. Ash% was maximum 79.75 for queous extract and minimum for haxene extract which was 30.76%. For Bacopa monnieri extractive value were 25.94±0.69, 36.56±0.98, 43.05±1.23, 35.37±1.2, 54.63±1.74, 65.52±1.030, 72.09±0.87 for respective solvents. Ash% was maximum 64.94 for pet ether extract and minimum for ethanol extract which was 54.03%.

Authors :
Pallav Kaushik Deshpande and Ragini Gothalwal : Department of Biotechnology, Barkatullah University, Bhopal,(M.P):462026