Preparation of Chitin-Glucan Microsphere via Spray-Drying Technique and their Antibacterial Activity

By : Anu Singh, P. K. Dutta

Page No: 63-69

Abstract
The experiment was designed to examine the microsphere of the chitin-glucan complex. We formed a chitin-glucan microsphere (ChGMS) from the spray dryer technique. SEM images observed that shape of ChGMS was spherical. From particle size analyzer and SEM analysis both showed that the size of particles was in the range of 1.5 to 3.5 ?m. It showed amorphous nature after the formation of microsphere particles of chitin-glucan. The effect of chitin-glucan complex and ciprofloxacin loaded chitin-glucan microsphere on Bacillus subtilis and Escherichia coli were also tested. Antibacterial analysis was indicating that the ciprofloxacin loaded chitinglucan microsphere strongly inhibited the growth of bacteria in comparison to the chitin-glucan solution. From the analysis, we can conclude that the antibacterial property was also dependent on the size of the chitin-glucan microsphere. Complexation of the chitin-glucan microsphere with ciprofloxacin improved the antibacterial activity of the chitin-glucan microsphere.

Authors :
Anu Singh
Polymer Research Group, Department of Chemistry, Motilal Nehru National Institute of Technology Allahabad, Prayagraj-211004, India.

P. K. Dutta
Polymer Research Group, Department of Chemistry, Motilal Nehru National Institute of Technology Allahabad, Prayagraj-211004, India.
 

DOI: https://doi.org/10.32381/JPM.2021.38.1-2.6