Preparation of Dual-Responsive Nanogels for Controlled Release of Insulin

By : Lei Li, Guohua Jiang, Tengteng Jiang, Qin Huang, Hua Chen, Yongkun Liu

Page No: 77-84

Abstract
The polymeric nanogels were prepared by the copolymerization of polyethylene glycol methyl acrylate (PEGMEM) and 3-acrylamide phenylboronic acid (AAPBA) using N, N-methylene bis acrylamide (BIS) as cross-linking agent. The as-prepared nanogels were characterized by 1 H NMR, FT-IR, transmission electron microscopy (TEM), and dynamic light scattering (DLS). Due to the pH sensitivity and the glucose-sensitivity of as-prepared nanogels, the nanogels could be used to encapsulate insulin. The insulin release properties of nanogels under different pH and glucose concentrations were investigated. These results showed that the nanogels are one of effective candidate carriers for insulin release.

Authors :
Lei Li, Guohua Jiang, Tengteng Jiang, Qin Huang, Hua Chen and Yongkun Liu : Department of Materials Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China