Formulation and Evaluation of Microspheres of Fluoxetine Hydrochloride using different Biopolymers

By : Alia Erum , Sara Afreen , Aisha Rauf , Uzma Saleem

Page No: 759-770

Abstract
The present study was designed to investigate the use of different biopolymers in the formulation and release profile of Fluoxetine hydrochloride microspheres prepared by using ionotropic gelation method. Main purpose was comparing and selecting best suitable polymer among different polymers such as sodium alginate, chitosan, arabinoxylan and hydroxypropyl methylcellulose (HPMC). All the formulations were evaluated in terms of percentage yield, percentage encapsulation efficiency, flow properties, FTIR and SEM analysis and in vitro release characteristics. Percentage yield, encapsulation efficiency and flow properties of of all tested formulation were satisfactory. As far as in vitro drug release studies were concerned, F7 showed the best sustained release characteristics. Dissolution data modeling showed Krosmeyer peppas model following non-Fickian and super case II transport mechanism for drug release. In conclusion chitosan arabinoxylanin (2:1) are suitable polymer combination for microsphere formulation of Fluoxetine hydrochloride.

Authors :
Alia Erum, Sara Afreen and Aisha Rauf : Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan
Uzma Saleem : College of Pharmacy, Government College University, Faisalabad, Pakistan