Novel Chitosan Nanoparticles as Drug Carriers in Cancer Therapy

By : Vaidehi. D, V. Bhuvaneshwari, R. Amsaveni, A. Sivaranjini, M. Kalaiselvi

Page No: 197-206

Abstract
Cancer is one of the major dreadful diseases which have gained a lot of scientific attention worldwide. Current anticancer chemo drugs agents are restricted due to their low solubility in water, multidrug resistance problems and serious side effects to healthy tissues. Nanocarriers are designed to deliver anticancer drugs to the targeted cancerous tissues and prevent from side effects. Recent decades, Chitosan Nanoparticles (CS NPs) have attracted significant attention of researchers due to its unique properties such as biodegradability, low toxicity, biocompatibility, stability, ease of chemical modification, simple and mild preparation method. CS NPs are very good drug carriers for anticancer chemical drugs, gene drugs and loading protein drugs in cancer therapy. In this review, we focused the methods of preparation of CS NPs and their potential application as nanocarriers for anticancer drug.

Authors :
Vaidehi. D, V. Bhuvaneshwari, R. Amsaveni and A. Sivaranjini : PG and Research Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore-641029, Tamilnadu
M. Kalaiselvi : Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore-641029, Tamilnadu