Development of Chitosan-tri Polyphosphate Nanomaterials for Oral Delivery of Insulin

By : Sheena Devasia , Meenu Sukumarana , Suresh Kumar Js

Page No: 75-89

Abstract
Oral delivery is an attractive route to deliver therapeutics via nanomaterials due to its ease in administration and patient compliance. As chitosan is a biodegradable and biocompatible polymer with good mucoadhesive and membrane permeability properties, it can be used as an ideal drug delivery carrier. Chitosan of three different degree of deacetylation (DA) and viscosity (Sample A-60cps 84.5% DA, Sample B -90cps 86% DA, and Sample C-20cps 94.9% DA) were selected for the study. Chitosan –Tri Poly Phosphate (TPP) nanoparticles was prepared by ionic gelation method and insulin was incorporated to it. Swelling studies were conducted at pH 1.2, 6.8 and 7.4 until there was no further increase in weight. In vitro release studies were conducted in the pH buffers as a function of time. pH responsive GI tract model study was also done to mimic the invivo condition by doing invitro test and the pH/buffer selection is based on the exposure of drug from stomach to intestine /colon and ensure the impact of pH changes on dissolution and release of drug for absorption.

Authors :
Sheena Devasia, Meenu Sukumarana and Suresh Kumar Js : Nitta Gelatin India Limited, KINFRA Export Promotional Industrial Park, INFOPARK PO, Kakkanad, Kochi-682042, Kerala, India