Preparation and Characterization of Chitosan based Hydrogel Formulation by using Acetic acid and Propylene glycol for Wound Healing Application

By : Madhu Kashyap, Joydeep Dutta, P.K. Dutta

Page No: 33-44

Abstract
Hydrogels have drawn great attention to researchers for its versatile kinds of properties, particularly in biomedical fields of research. The present hydrogels prepared by using chitosan as base material and acetic acid (aq) and propylene glycol as solvents for wound healing application. The durability of the hydrogels were lasted for prolong duration and its physico-chemical and biological properties were evaluated in a systematic manner. The microbiological screening has demonstrated the positive cellular mouse skin fibroblast activity against cell line (NIH 3T3). Viability was measured based on the esterase enzyme activity and plasma membrane integrity by FDA assay. The assays for cell proliferation and viability showed that prepared hydrogel was biocompatible. The studies of swelling and drug delivery were conducted with impressive results. Overall, this finding indicates the suitability of prepared hydrogel for wound healing application.

Authors :
Madhu Kashyap : Department of Chemistry, Nehru Gram Bharati Vishwavidyalaya, Kotwa- Jamunipur, Dubawal, Allahabad-221505, India
Joydeep Dutta : Department of Chemistry, Amity school of Applied Sciences, Amity University, Haryana, Pachgaon, Near IMT Manesar, Haryana-122413, India
P.K.Dutta : Department of Chemistry, MN National Institute of Technology, Allahabad-211004, India