Chitosan Nano-composite containing Undecatungstosilicate via Cobalt Substitution: Characterization and Evaluation of their Biological Activity

By : Shiva Arun , Yadvendra Singh , Amreen Naz , Prabha Bhartiya , Shahid Suhail Narvi , Pradip Kumar Dutta , Kshama Srivastava

Page No: 305-316

Abstract
Encapsulation of polyoxometalates into chitosan have drawn tremendous attraction of researchers in biomedical science. Chitosan (CS) is widely studied for its significant biomedical applications. In this study we have synthesized a nano-composite by encapsulating a cobalt substituted lacunary undecatungstosilicate [CoSiW11O39(H2 O)]6-, intobiocompatible chitosan. The combination of polyoxometalate with chitosan is not merely physical mixture but indeed it is nano-composite formed by electrostatic interaction between anionic polyoxometalate and cationic chitosan. The resulting nano-complex, (CoSLPOM-CS) was characterized by FT-IR, UV-Vis spectra, energy dispersive X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM) and Dynamic light scattering (DLS). FTIR and UV-Vis spectra analysis confirms the successful encapsulation of cobalt substituted lacunary polyoxometalate into chitosan. The antibacterial activity of CoSLPOM, chitosan and CoSLPOM-CS were tested against bacterial strains of B. subtilis gram (+) ve and P. aeruginosa gram (-) ve. The CoSLPOM-CS showed enhanced antibacterial activity as compared to bare CoSLPOM and chitosan. The nano-complex, CoSLPOM-CS was further investigated for drug delivery and it exhibited excellent drug loading efficiency.

Authors :
Shiva Arun, Yadvendra Singh, Amreen Naz, Prabha Bhartiya , Shahid Suhail Narvi and Pradip Kumar Dutta : Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad-211004, India
Kshama Srivastava : Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow-226025, India
 

DOI: https://doi.org/10.32381/JPM.2018.35.03.5