Sensitive Response of Chitosan Encapsulated Ibuprofen Microspheres to the narrow pH range for Drug Delivery System

By : Ran Yan, Li Lei, Shougang Chen, Fei Yu

Page No: 195-207

Abstract
Controlled drug-delivery and release systems have received increasing attention for biomedical applications. Chitosan encapsulated ibuprofen (IBU@CS) microspheres were prepared according to oil-in-water micro emulsion polymerization method for an excellent narrow pH sensitive response targeted drug delivery system. The morphology and chemical composition of IBU@CS microspheres with different formulations were characterized. The cytotoxicity test was studied by MTT assay. Results showed that the IBU@CS microspheres were in a spherical structure with a diameter in the range of 50 nm-300 nm. The IBU@CS microspheres had no toxic effect on cells. The in vitro IBU release experiments in PBS solutions of pH 6.8 and 7.4 showed that the encapsulation of CS to IBU could not only reduce the release rate of IBU, but also make the microspheres have narrow pH sensitivity which can release IBU under pH of the inflammatory tissues (pH 6.8) more easily than that of normal tissues. This IBU@CS pH-responsive release system can provide a promising control-release manner to achieve a good therapeutic effect for localized drug delivery.

Authors :
Ran Yan, Li Lei and Shougang Chen : School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China
Fei Yu : Institute for Translation Medicine, Qingdao University, Qingdao 266100, China
 

DOI: https://doi.org/10.32381/JPM.2018.35.02.5