Nanoarchitecture CD@CMC@MnSiO3 : A dual responsive drug delivery system with cellular imaging ability

By : Prabha Bhartiya, P.K. Dutta

Page No: 85-101

Abstract
Designing theranostic agents that are responsive to mildly acidic and reducing tumor microenvironments for optimized imaging and chemotherapeutic effects, is of huge interest in nanomedicine. In this context, we have prepared mesoporous manganese silicate NPs and a biocompatible coating of carboxymethyl chitosan (CMC) was introduced on the surface of manganese silicate nanoparticles. In order to confer multifunctionality to the prepared nanovehicle, it was treated hydrothermally which resulted in formation of fluorescent C-dots on the surface of nanovehicle. The nanoarchitecture CD@CMC@MnSiO3 was characterized by FTIR, XRD, UV-visible and PL spectroscopy. A hydrophobic drug curcumin was loaded on the prepared nanoarchitecture and very high drug loading capacity was obtained. Drug release profile was observed at physiological pH (pH 7.4), acidic pH (pH 6.4 and 5.0) and acidic pH with reducing environment (pH 5.0 and glutathione). The prepared nanoarchitecture demonstrated exceptional pH-modulated drug release which was further enhanced in the presence of glutathione. Cellular imaging experiments conducted on SW480 cell lines confirmed potential applicability of the prepared nanoarchitecture for live cellular imaging which may also be applied for tracking of drug.

Authors :
Prabha Bhartiya and P.K. Dutta :  Polymer Research Laboratory, Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad-211004, India
 

DOI: https://doi.org/10.32381/JPM.2018.35.01.7