MAVS in Fish Antiviral Response- A Mini Review

By : Abisha Juliet Mary.S.J , Dhayanath. M , G. Vijay Sundar Deva

Page No: 197-207

Abstract
The immune system in an organism is answerable for clearing pathogens which is implemented by the coordinated use of innate and adaptive immune components of its immune system. Bony fish represents a transition factor on the phylogenetic spectrum between species possessing simplest innate immunity (i.e., invertebrates) and species relying heavily on adaptive immunity (i.e., mammals). Research on host response to virus infections suggests that mammals and bony fish are more or less similar within the predominant mechanisms of each innate and adaptive immune response towards viruses. This review focuses on the main concept of MAVS which is an adapter protein acting to create an antiviral cellular state. This protein is required for the phosphorylation of IRF3 and I?B and functions downstream of RIG-I.

Authors :
S.J. Abisha Juliet Mary, M.Dhayanath1 and G. Vijay Sundar Deva
Aquatic Environment and Health Management Division, Central Institute of Fisheries Education, Mumbai.
 

DOI: http://doi.org/10.32381/JAT.2019.34.3-4.6