Factor Screening for Formulation Development of a Novel Combined Nano Drug Delivery System using Taguchi Method 

By : Nabanita Mukherjee, Rita Lala, Indrajit Mukerjee

Page No: 101-116

Abstract
An antihyperlipidemic drug like Atorvastatin calcium (ATC) suffers from poor oral bioavailability due to low solubility and first-pass metabolism by the liver. Combination of cholesterol synthesis inhibitor (ATC) and cholesterol absorption inhibitor (Ezetimibe) lowers the cholesterol level more than ATC alone. The combined drug can also reduce the risk of Type II diabetes mellitus due to use of a lower dose of atorvastatin calcium, particularly for geriatric patients. The objective of this work is to screen critical factors for developing a novel combined antihyperlipidemic drug delivery system in nanostructured lipid carrier (NLC) considering percent drug loading, and particle size(nm), as responses. Taguchi’s L8 orthogonal array design with replicates was used to screen factors. TEM study and zeta potential study of the optimal formulation was done which shows formulation within nanometric size range with high stability. Results indicate all four factors are critical to determining optimal formulation.

Authors :
Nabanita Mukherjee
Principal K M Kundnani College of Pharmacy, Mumba.

Rita Lala
Principal K M Kundnani College of Pharmacy, Mumba.

Indrajit Mukherjee
Shailesh J. Mehta School of Management, IIT Bombay.

DOI: DOI-https://doi.org/10.32381/IAPQRT.2019.43.02.1